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how long does prednisone stay in your system - The elimination half-life of prednisone, a commonly prescribed corticosteroid medication, is approximately 2 to 4 hours. However, it takes about five half-lives for a drug to be mostly eliminated from the body. Therefore, prednisone is typically cleared from the system within 10 to 20 hours after the last dose. However, individual factors such as metabolism, dosage, and duration of use can affect the exact timeline. It's important to follow the instructions of your healthcare provider and consult them for specific information regarding prednisone elimination.